MicroRNA 652 (miR-652)

MicroRNA 652 (miR-652) is a short, non-coding RNA molecule belonging to the microRNA family that is encoded in the human genome and regulates gene expression at a post-transcriptional level. miR-652 is transcribed by RNA polymerase II and processed via Drosha and Dicer enzymes to generate mature miRNA, which is incorporated into the RNA-induced silencing complex (RISC) to modulate mRNA stability and translation[3]. miR-652 has emerged as a key regulator in cancer biology; it exerts tumor-suppressive effects in glioblastoma multiforme by targeting transcription factors such as FOXK1 and deactivating the AKT/mTOR pathway, thus inhibiting cell proliferation, migration, and promoting apoptosis[1]. In contrast, miR-652 may promote tumorigenesis and metastatic phenotypes in other cancer types depending on cellular context and specific mRNA targets[2][4]. Expression levels of miR-652 can have diagnostic and prognostic significance, including as a biomarker for poor prognosis in GBM and other cancers. As with other miRNAs, therapeutic manipulation of miR-652 is being explored as a potential strategy in molecular-targeted therapies; however, there are concerns over specificity and context-dependent effects[1][4].

Other names

MIR652hsa-mir-652MIRN652