microRNA-654 (miR-654)

microRNA-654 (miR-654) is a small non-coding RNA molecule (microRNA) involved in the post-transcriptional regulation of gene expression. It is transcribed from the MIR654 gene and gives rise to mature functional species miR-654-3p and miR-654-5p, each with distinct target profiles and biological actions. miR-654 regulates diverse processes, including apoptosis, cell proliferation, migration, fibrosis, and metabolism, often by binding complementary sequences in the 3′UTRs of target mRNAs to repress translation or enhance degradation. miR-654-3p and miR-654-5p are implicated in tumorigenesis (displaying both tumor-suppressor and oncogenic properties depending on context), chemoresistance, myocardial infarction injury, pyroptosis, mitochondrial metabolism, and liver fibrosis. Their expression levels can serve as biomarkers for disease prognosis and treatment response. While promising as possible therapeutic targets, their pleiotropic roles and context-specific actions pose challenges for clinical translation[1][3][5][7].

Other names

hsa-miR-654MIR654MIRN654mir-654miR-654-3pmiR-654-5p

Suppression of target mRNA translation or promotion of target mRNA degradation through direct binding to 3′ UTR. Regulation of pathways such as PI3K/AKT (cisplatin sensitivity), RTK signaling, and modulation of proteins involved in EMT and fibrosis