MicroRNA 663a (miR-663a)

MicroRNA 663a (miR-663a) is a small, non-coding RNA molecule that post-transcriptionally regulates gene expression by targeting mRNAs for degradation or translational repression. It has a key role in controlling cell proliferation, cell cycle progression, and cellular migration/invasion, partly through the regulation of target genes such as JunD and TTC22V1[2][3]. Downregulation of miR-663a is associated with increased cancer progression and metastasis in several cancers, including colon and non-small cell lung cancer, where it typically acts as a tumor suppressor[2][3]. Higher levels have also been associated with cancer progression in certain prostate cancer contexts[4], underscoring its complex, tissue-specific functions. Its expression profiles can serve as biomarkers for cancer diagnosis or prognosis. While not currently the target of any approved drugs, miR-663a is a focus of research using oligonucleotide-based mimics or inhibitors that may modulate its therapeutic potential.

Other names

hsa-miR-663aMIR663AmiR-663aMIR663MIRN663hsa-mir-663hsa-mir-663amir-663amicroRNA 663microRNA-663a

Post-transcriptional gene silencing: miR-663a binds to the 3′ untranslated region (UTR) of specific target mRNAs (e.g., JunD, TTC22V1), resulting in their degradation or translational repression. miRNA sponging: Competing endogenous RNAs (e.g., lncRNA MALAT1) can sequester miR-663a, modulating its regulatory effects.