microRNA 664b (miR-664b)

MicroRNA 664b (miR-664b, hsa-miR-664b) is a non-coding RNA molecule classified as a microRNA, typically transcribed as a precursor and processed to form one or more mature regulatory sequences (notably miR-664b-3p and miR-664b-5p) that regulate mRNA expression post-transcriptionally. Experimental studies indicate that miR-664b is involved in diverse biological processes such as regulation of cell morphogenesis, nervous system development, and cellular translation. In cancer, miR-664b shows context-dependent expression changes: it is differentially expressed in breast cancer—associated with both oncogenic and tumor suppressor roles—and is downregulated in skeletal muscle with aging, suggested as a biomarker for muscle decline. Its molecular mechanism involves base-pairing with target mRNAs to inhibit translation or promote degradation, although the exact target repertoire and effects are incompletely mapped. Therapeutic targeting remains investigational, with no approved drugs known to modulate its activity directly[1][2][5].

Other names

hsa-miR-664bmiR-664b-3pmiR-664b-5p