microRNA 6741 (miR-6741)

microRNA 6741 (miR-6741), specifically its mature form miR-6741-3p, is a human intronic microRNA located within the PYCR2 (Pyrroline-5-carboxylate reductase family, member 2) gene. It functions as a post-transcriptional regulator of gene expression and has been recently identified to have tumor-suppressive properties in oral squamous cell carcinoma (OSCC). Overexpression of miR-6741-3p decreases cell proliferation, promotes apoptosis, and directly targets the oncogene SRSF3, repressing its translation without affecting mRNA levels. The regulation by miR-6741-3p appears to modulate oncogenic signaling pathways, especially the ERK/MAPK pathway, and its expression can be upregulated by demethylating agents such as 5-Azacytidine, suggesting an epigenetic component to its regulation. miR-6741 functions as a classical microRNA with no confirmed direct drug interactions or use as a clinical biomarker, but its tumor-suppressive role in cancer highlights its potential therapeutic relevance[1].

Other names

hsa-miR-6741hsa-mir-6741microRNA mir-6741MIR6741miR-6741-3p

miR-6741-3p acts by *post-transcriptional repression* of specific mRNA targets, notably: - Translational inhibition of SRSF3 (serine/arginine-rich splicing factor 3) oncogene without degrading its mRNA, resulting in reduced oncogenic protein expression and decreased proliferation in cancer cells[1].