MicroRNA 6744 (miR-6744)

MicroRNA 6744 (miR-6744) is a small non-coding RNA molecule that regulates gene expression post-transcriptionally by binding to target mRNAs and reducing their translation or promoting degradation. MiR-6744-5p plays a key tumor suppressive role in breast cancer cell lines by promoting anoikis, a form of apoptosis induced by loss of cell attachment to the extracellular matrix, thereby acting as a barrier to metastasis. Experimental studies show that miR-6744-5p is downregulated in anoikis-resistant breast cancer sublines, and overexpression restores sensitivity to anoikis while decreasing migration and invasiveness. The N-acetyltransferase 1 (NAT1) enzyme was identified as a direct downstream target of miR-6744-5p, linking its regulatory function to key processes in cell survival, EMT, and metastatic progression. Expression levels of miR-6744-5p, as well as its impact on E-cadherin, highlight its importance as a potential therapeutic target and biomarker in breast cancer.

Other names

MIR6744miR-6744-5phsa-mir-6744microRNA mir-6744microRNA-6744-5p

miR-6744-5p functions by downregulating target mRNA, specifically the N-acetyltransferase 1 (NAT1) enzyme, resulting in increased sensitivity to anoikis and decreased migration/invasion in breast cancer cells