MicroRNA 675-3p (miR-675-3p) (miR-675-3p)

MicroRNA 675-3p (miR-675-3p) is a short, non-coding RNA molecule derived from the first exon of the long non-coding RNA (lncRNA) H19. It functions as a post-transcriptional regulator of gene expression, typically by binding to the 3' untranslated regions (UTRs) of target mRNAs to induce gene silencing or translational repression. miR-675-3p is involved in diverse biological processes, including skeletal muscle differentiation, placental development, and osteogenesis. In clinical contexts, it is frequently upregulated in various malignancies, such as gastric cancer, melanoma, and hepatocellular carcinoma, where it promotes tumor progression, metastasis, and cell cycle advancement. Additionally, it serves as a significant biomarker for cardiovascular diseases, particularly atherosclerosis, where elevated serum levels correlate with poor prognosis and increased carotid intima-media thickness. Therapeutic targeting of miR-675-3p involves the use of synthetic mimics or antagomirs to modulate its activity, although challenges such as off-target effects and delivery to specific tissues remain prominent. Some natural compounds, such as curcumin, have been shown to influence the H19/miR-675 axis, suggesting potential for dietary or small-molecule intervention.

Other names

hsa-miR-675-3pmiR-675H19-derived miR-675-3p

Post-transcriptional gene silencing via RNA-induced silencing complex (RISC) binding to target mRNA 3' UTRs, leading to mRNA degradation or translational inhibition.