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Target intelligence / Profile preview
microRNA 6750 (miR-6750)
- Target
- miR-6750
- Molecular classification
- microRNA, non-coding RNA
01
Overview
microRNA 6750 is a small, non-coding RNA that regulates gene expression primarily through post-transcriptional repression. It is found enriched in small extracellular vesicles in healthy individuals compared to patients with nasopharyngeal carcinoma, and its presence is associated with suppression of metastasis, inhibition of angiogenesis, and promotion of anti-tumor immune phenotypes in macrophages. It acts by silencing target genes, notably mannose 6-phosphate receptor (M6PR), and may play a significant role in remodeling the tumor microenvironment. While its molecular function is still being explored, miR-6750 is highlighted as a potential diagnostic and therapeutic marker for cancer progression, especially in NPC.
- Other names
- MIR6750hsa-mir-6750microRNA mir-6750
02
Mechanism of action
Post-transcriptional repression of target genes (notably directly targets mannose 6-phosphate receptor, M6PR); Inhibition of angiogenesis and metastasis via SEV-mediated transfer to macrophages and endothelial cells
03
Biological functions
Regulation of cell communicationAngiogenesis inhibition in tumor microenvironmentMacrophage polarization toward M1 phenotypePost-transcriptional gene silencing
04
Disease associations
Cancer (especially nasopharyngeal carcinoma)Tumor metastasis regulationModulation of pre-metastatic niche
05
Safety considerations
Potential off-target effects typical of RNA-targeted therapiesChallenge of specific delivery and stable expression modulation in vivo
06
Biomarkers
Circulating miR-6750 in serum small extracellular vesicles (SEVs) as a potential marker for nasopharyngeal carcinoma metastasis
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