microRNA 676 (MIR676)

microRNA 676 (MIR676) is a conserved small non-coding RNA functioning as a post-transcriptional regulator of gene expression. It is involved in critical cellular processes including cell proliferation, apoptosis, neuroprotection, and metabolic regulation. In cancer, MIR676 expression is closely associated with tumor phenotype and can sensitize cells to chemotherapeutic agents, such as metformin, by promoting apoptosis and cell cycle arrest. Its neuroprotective role is linked to antiapoptotic activity following brain injury. MIR676 acts through base pairing with target mRNAs for gene silencing, and its regulatory impact may be modulated by proteins such as p53. Dysregulation of MIR676 is implicated in various diseases, most notably cancer and neurological disorders, making it a candidate biomarker and potential therapeutic target.

Other names

hsa-mir-676mir-676MIR676rno-miR-676-1mmu-mir-676miR-676-3p

Gene silencing via binding to 3′UTR of target mRNA, leading to repression or degradation. Cooperativity: miRNAs can synergize via TNRC6 proteins for stronger repression. Drug sensitization: miR-676-3p increases cell sensitivity to metformin via apoptosis and cell cycle arrest.