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microRNA 6807 (MIR6807)

Target: MIR6807
Molecular classification: MicroRNA, Non-coding RNA

Overview

MicroRNA 6807 (MIR6807) is a small, single-stranded non-coding RNA of 21–23 nucleotides, expressed in humans (hsa-mir-6807); it functions primarily in post-transcriptional gene regulation by binding to target mRNAs, leading to their silencing or degradation. Its expression is altered in colorectal cancer, though definitive molecular targets and mechanisms remain unclear. As with other microRNAs, MIR6807 may regulate cellular processes such as cell proliferation and apoptosis and may serve as a biomarker for disease diagnosis and prognosis, pending further research[1][2][3][4].

Other names: hsa-mir-6807microRNA mir-6807MIR6807miRNA-6807-5p

Biological functions

Gene expression regulation (post-transcriptional silencing via RNA interference mechanisms)mRNA targeting and degradationPotential involvement in cell cycle, apoptosis, and proliferation, as is common among miRNAs (inferred from miRNA biology as detailed for other miRNAs)

Disease associations

Cancer (colorectal cancer: inverse correlation seen with ZG16 in colorectal carcinogenesis, though direct target relationship is uncertain)Other disease roles for miRNAs could include inflammation, neurodegenerative diseases, or cardiovascular conditions, but specific evidence for MIR6807 is currently limited

Safety considerations

No specific therapeutic safety concerns described for targeting MIR6807, though miRNAs in general pose delivery and off-target effects challenges

Biomarkers

Possible role as a biomarker for colorectal cancer progression—its expression is altered in disease stages, but clinical validation is pending

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