MicroRNA 6852 (miR-6852)

MicroRNA 6852 (miR-6852), also known as hsa-miR-6852 or miR-SX4, is a human microRNA—part of a class of small, non-coding RNAs involved in post-transcriptional regulation of gene expression. miR-6852 has been identified as differentially regulated by immunomodulatory cytokines such as interleukin-27 and demonstrates tumor suppressor properties. Functionally, miR-6852 induces cell cycle arrest at the G2/M phase and triggers necrosis in a variety of cancer cell lines, including cervical and colorectal cancers. In cervical cancer cells, its overexpression leads to downregulation of the transcription factor FoxM1 and several downstream targets involved in cell cycle progression and survival[1]. In colorectal cancer, miR-6852 is underexpressed in tumors compared to normal tissue, with lower expression associated with lymph node metastasis and poorer prognosis. Mechanistically, miR-6852 directly targets TCF7—a transcription factor central to the Wnt/β-catenin signaling pathway, a crucial axis in colorectal cancer biology. Elevated miR-6852 expression is associated with reduced proliferation and invasiveness of tumor cells, suggesting a tumor-suppressive role and potential as a prognostic biomarker in colorectal cancer[2]. No direct drug interactions are known, though modulating its activity is being explored for therapeutic strategies. Safety concerns include the potential for widespread off-target gene regulation typical for microRNAs.

Other names

hsa-mir-6852hsa-miR-6852miRNA-6852miR-SX4microRNA mir-6852

Not applicable for conventional pharmacology; miR-6852 acts through post-transcriptional gene regulation, downregulating targets such as FoxM1 (for cervical cancer) and TCF7 (for colorectal cancer)[1][2].