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microRNA 6859-3 (miR-6859-3p)
- Target
- miR-6859-3p
- Molecular classification
- microRNA, non-coding RNA, regulatory RNA
01
Overview
microRNA 6859-3 (miR-6859-3p) is a human microRNA implicated in post-transcriptional regulation of gene expression. Recent studies identified miR-6859-3p as an indirect modulator of SOX9 mRNA and protein levels in breast cancer cell lines; its repressive effects on SOX9 appear to be mediated via complex regulation of transcriptional activators and other microRNAs rather than direct binding to the SOX9 3′UTR. Unlike classic therapeutic targets, miR-6859-3p functions as part of a regulatory network, influencing cellular pathways such as chromatin organization and cell cycle control. Its role in cancer biology may be cell-type specific and indirect; no drugs currently target miR-6859-3p, and it is not used as a clinical biomarker or has identified safety liabilities.
- Other names
- hsa-miR-6859-3pMIR6859-3microRNA mir-6859-3pmiR-6859-3p
02
Biological functions
Regulation of gene expression (by partial base pairing to mRNAs, leading to translational repression or mRNA degradation)Modulation of pathways involving chromatin organization and cell cycle regulation in specific contexts
03
Disease associations
Potential involvement in breast cancer cell biology, specifically in modulation of SOX9 expression (which is implicated in cell proliferation and tumor growth)
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