MicroRNA 6891 (MIR6891)

MicroRNA 6891 (MIR6891) is a short (~22 nucleotide), non-coding RNA transcript derived from intron 4 of the HLA-B gene, classifying it as a mirtron microRNA[1][2][3]. It is processed by the Dicer enzyme into mature miR-6891-5p and miR-6891-3p strands. As with other microRNAs, it participates in post-transcriptional gene silencing by binding target mRNA transcripts—most notably, it regulates IGHA1 and IGHA2, influencing immunoglobulin A (IgA) expression in B lymphocytes[1]. MIR6891 may have a role in immune function and selective IgA deficiency, a condition characterized by low or absent IgA. No drugs currently target MIR6891, it is not an established therapeutic receptor or enzyme, and there is no known direct link to major diseases beyond immunological processes[1][2][3].

Other names

hsa-mir-6891microRNA mir-6891MIR6891-5pMIR6891-3p

RNA-induced silencing complex (RISC) loading for mRNA degradation or translational repression Post-transcriptional inhibition of IGHA1 and IGHA2 via non-canonical binding to 3’UTR