microRNA-7-3p (miR-7-3p)

microRNA-7-3p (miR-7-3p) is a mature microRNA derived from the passenger strand (formerly miR-7*) of the miR-7 precursor, which is encoded by three distinct genomic loci: MIR7-1, MIR7-2, and MIR7-3. While historically considered a byproduct of miRNA processing, miR-7-3p is now recognized as a functional regulator of gene expression that plays a significant role in various physiological and pathological processes. It primarily acts as a tumor suppressor by targeting oncogenic mRNAs such as STAT3, BCL-2, and XIAP, thereby inhibiting cell proliferation, migration, and survival in several cancers, including head and neck, gastric, and thyroid cancers. In addition to its role in oncology, miR-7-3p is involved in regulating immune responses and metabolic pathways, such as the AMPK signaling pathway. Therapeutic strategies targeting miR-7-3p include the use of miRNA mimics to restore its expression in cancer or antagomirs to inhibit its function in specific contexts. Additionally, phytochemicals like luteolin and silibinin have been shown to enhance the anti-cancer effects of miR-7-3p in preclinical models. Despite its therapeutic potential, challenges such as off-target effects and the need for efficient delivery systems remain significant hurdles for its clinical application.

Other names

hsa-miR-7-3pmiR-7*microRNA-7-3pmiR-7-1-3pmiR-7-2-3pmiR-7-3-3p

Binds to the 3'-untranslated region (3'-UTR) of target mRNAs, such as STAT3, BCL-2, and XIAP, to inhibit their translation or promote their degradation, thereby regulating key oncogenic and inflammatory pathways.