MicroRNA-711 (miR-711)

MicroRNA-711 is a small, endogenous non-coding RNA molecule classified as a microRNA, participating mainly in the post-transcriptional regulation of gene expression by binding to complementary sequences in the 3’ untranslated regions (UTRs) of target mRNAs to repress translation or induce degradation. It is involved in various cellular processes including cell proliferation, apoptosis, cell cycle control, and immune signaling. MicroRNA-711 exhibits disease-dependent functional diversity: it acts as a tumor suppressor in prostate cancer by being downregulated in more aggressive and metastatic disease, but is upregulated and shows oncogenic properties in breast cancer, associated with poor prognosis and increased cell proliferation. Additionally, miR-711 serves as a diagnostic biomarker for cutaneous T-cell lymphoma and has been implicated in non-malignant conditions such as traumatic brain injury, myocardial infarction, and insulin resistance. Remarkably, extracellular miR-711 is also capable of directly binding and activating the TRPA1 ion channel, independently of canonical mRNA-mediated effects, which may mediate certain sensory and neuronal signaling effects. No approved drugs are known to target this miRNA directly, but its role as a biomarker and potential therapeutic target is supported by multiple studies.

Other names

hsa-miR-711MIR711hsa-mir-711mir-711

Post-transcriptional regulation of gene expression by binding mRNA; Direct extracellular activation of TRPA1 ion channel