MicroRNA-758 (miR-758)

MicroRNA-758 (miR-758) is a short non-coding RNA molecule (microRNA) involved in the post-transcriptional regulation of gene expression in human cells[1]. It is processed from primary transcripts via the canonical miRNA maturation pathway into a mature miRNA that is then incorporated into the RNA-induced silencing complex (RISC), where it guides repression of specific messenger RNAs through partial base-pairing, resulting in translational inhibition or mRNA destabilization[1]. miR-758 is highly expressed in the brain and is a key regulator of cholesterol metabolism, specifically by repressing ATP-binding cassette transporter A1 (ABCA1), thereby affecting cellular cholesterol efflux particularly in neural and macrophage cells[2][5]. It also targets a range of genes involved in neurological function (e.g., Slc38a1, Ntm, Epha7, Mytl1)[2]. In cancer, miR-758 is generally downregulated and functions as a tumor suppressor. It inhibits cancer cell proliferation, migration, invasion, and epithelial-mesenchymal transition, at least in part by targeting oncogenes such as HMGB3 and MTDH and suppressing the Wnt/β-catenin signaling pathway[3][4][6]. miR-758 downregulation has been associated with tumor progression in cervical cancer, osteosarcoma, and tongue squamous cell carcinoma[3][4][6]. No direct interacting drugs or therapeutic agents selectively modulating miR-758 have been clinically established, but its roles in cholesterol metabolism and cancer biology have made it a subject of interest for future drug development strategies[1][2][3]. Due to its centrality in multiple disease pathways, therapeutic modulation of miR-758 could have diverse effects, and careful consideration of safety, particularly related to lipid metabolism and neural effects, would be required.

Other names

hsa-mir-758MIRN758mir-758MIR758

Post-transcriptional silencing of target mRNAs (notably ABCA1, HMGB3, MTDH, others)