microRNA 760 (miR-760)

microRNA 760 (miR-760) is a small non-coding RNA that regulates gene expression post-transcriptionally, typically by binding to complementary sequences in the 3′-untranslated regions (UTRs) of target mRNAs, leading to their degradation or translational inhibition[3][2][4]. miR-760 has been identified as a tumor suppressor in multiple cancers, including gastric, colorectal, non-small cell lung, esophageal, and glioma, often showing decreased expression in tumor tissues relative to normal tissues[1][2][4]. Its mechanisms include downregulation of oncogenic pathways and target genes such as MMP2, SP1, PTEN/AKT, Notch1, and others, influencing proliferation, apoptosis, invasion, metastasis, and chemoresponse[1][2][3][4][5]. In addition to cancer, miR-760 is implicated in other pathological processes including intervertebral disc degeneration, where it modulates inflammation and extracellular matrix synthesis via the MyD88/NF-κB pathway[5]. Decreased miR-760 levels are often correlated with more advanced disease and poorer prognosis, and circulating miR-760 in plasma or serum is being investigated as a potential biomarker in oncology and other diseases[3]. No direct interacting drugs are established, but miR-760 mimics or inhibitors are proposed as experimental therapeutic tools, primarily in the context of cancer or tissue regeneration[5].

Other names

hsa-mir-760MIRN760mir-760MIR760

Modulates expression of oncogenic transcripts; Targets signaling pathways such as PTEN/AKT, Notch1, NF-κB; Suppresses or enhances chemoresistance in cancer cells.