MicroRNA 767 (miR-767)

MicroRNA 767 (miR-767; also known as MIR767, hsa-mir-767) is a small non-coding RNA of the microRNA class that regulates gene expression post-transcriptionally by targeting complementary mRNAs for degradation or translational repression. Elevated expression of miR-767, including its 3p and 5p isoforms, has been found in multiple malignancies such as hepatocellular carcinoma, non-small cell lung cancer, melanoma, glioblastoma, and osteosarcoma. In these contexts, miR-767 is implicated in promoting cell proliferation, enhancing metastasis, inhibiting apoptosis (for example, via targeting caspase-3 and caspase-9 in HCC), and regulating key tumor suppressor and epigenetic factors (such as TET1/TET3 in NSCLC). Paradoxically, in some contexts it may sensitize tumor cells to therapies. miR-767 is currently being investigated as both a therapeutic target and a biomarker for cancer prognosis and diagnosis[1][2][3][4].

Other names

miR-767MIR767hsa-mir-767mir-767MIRN767microRNA-767-3pmicroRNA-767-5p

Modulation of gene expression by binding to target mRNAs (usually results in mRNA degradation or translation inhibition); specific actions include inhibition of caspase-3/caspase-9 (HCC), regulation of TET1/TET3 (NSCLC), inhibition of CYLD (melanoma)[1][2].