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Target intelligence / Profile preview
microRNA 7973 (hsa-miR-7973)
- Target
- hsa-miR-7973
- Molecular classification
- microRNA, non-coding RNA
01
Overview
MicroRNA 7973 (hsa-miR-7973) is a human microRNA encoded within an intron of the *CYP19A1* gene. It acts as a post-transcriptional regulator by binding to complementary sequences in the 3′ untranslated regions of target mRNAs, leading to mRNA degradation or translational inhibition. hsa-miR-7973 is expressed in ovarian granulosa cells, where it contributes to follicle development and function, partly by modulating processes such as extracellular matrix remodeling and cell-cell communication. Experimentally validated target genes of miR-7973 include *ADAM19*, *PXDN* (Peroxidasin), *FMNL3*, *TGFBR2*, and *ATHL1*, which are implicated in extracellular matrix dynamics, cell adhesion, and possibly signaling pathways relevant to ovarian function.
- Other names
- hsa-miR-7973miR-7973
02
Mechanism of action
Binding to target mRNA 3′UTR and post-transcriptional silencing via the RNA-induced silencing complex (RISC)
03
Biological functions
Gene expression regulationPost-transcriptional silencingModulation of extracellular matrix and cell-cell interaction
04
Disease associations
Ovarian follicle development and maturationPotentially cancer (by involvement of target genes in proliferation/migration, though no direct disease link established for hsa-miR-7973)
05
Safety considerations
No direct safety concerns documented; general challenges may apply to miRNA-based therapies (off-target effects, delivery issues)
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