MicroRNA 8074 (MIR8074)

MicroRNA 8074 (MIR8074) is a single-stranded, non-protein-coding RNA of approximately 20–24 nucleotides, belonging to the microRNA class. Located on chromosome 19 (19q13.41), MIR8074 is processed via canonical miRNA biogenesis pathways (Drosha/Dicer-cutting, RISC loading). It regulates gene expression by targeting mRNA molecules for translational inhibition or degradation. MIR8074 has been found to regulate tumor-related genes including TP53 and MYC. In multiple myeloma, elevated MIR8074 is strongly associated with worse progression-free and overall survival, indicating its utility as a high-risk biomarker for prognosis assessment. While studies implicate MIR8074 in other conditions (e.g., cataract, osteoarthritis, metabolic syndrome), its biological functions and mechanisms of action remain incompletely characterized and do not yet support it as a direct therapeutic target[1][3]. MIR8074 is a microRNA—a non-coding RNA regulatory molecule—not a receptor, enzyme, transporter, or typical drug target class. Its best-evidenced role is as a prognostic biomarker in multiple myeloma, correlating with disease outcome but not directly modulated by current drugs. Data on direct disease mechanisms and drug interactions are limited, and MIR8074 is not considered a canonical therapeutic target at this time[1][3].

Other names

hsa-mir-8074microRNA mir-8074MIR8074

Not established for direct drugs targeting miR-8074; indirectly, changes in its expression may influence sensitivity/resistance to chemotherapeutics via regulation of genes like TP53 and MYC