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microRNA 8075 (miR-8075)

Target: miR-8075
Molecular classification: MicroRNA (miRNA), Non-coding RNA

Overview

microRNA 8075 (miR-8075) is a predicted non-coding RNA belonging to the microRNA family and was identified in bioinformatics screens for molecules binding the SARS-CoV-2 genome's 5' untranslated region. Like other microRNAs, it is likely processed from a precursor transcript by DROSHA and DICER nucleases. microRNAs contribute to gene silencing and post-transcriptional gene regulation by base-pairing to target mRNA. The specific biological functions, disease associations, or clinical significance of miR-8075 remain underexplored, though initial predictions suggest a role in viral infectivity for COVID-19. There are currently no drugs known to target miR-8075 directly, and its designation as a therapeutic target is not established.

Other names: hsa-mir-8075MIR8075microRNA mir-8075

Mechanism of action

RNA silencing: binds to target RNA and suppresses gene expression by degrading mRNA or inhibiting translation

Biological functions

Gene regulation via RNA silencingPost-transcriptional regulation of gene expression

Disease associations

Infection (predicted to bind the 5' UTR of the SARS-CoV-2 genome and potentially modulate viral infectivity)Other roles unknown due to limited data

Safety considerations

Altered microRNA expression profiles may have off-target or pleiotropic effects in gene regulation, but miR-8075-specific risks have not been reported

Biomarkers

Potential biomarker in viral infection, notably predicted as a marker for SARS-CoV-2 infection and host response

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