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Target intelligence / Profile preview
MicroRNA 8084 (MIR8084)
- Target
- MIR8084
- Molecular classification
- MicroRNA (miRNA), Non-coding RNA, Regulatory RNA
01
Overview
MicroRNA 8084 (MIR8084) is a small, non-coding RNA molecule (miRNA) that regulates gene expression post-transcriptionally, mainly by promoting mRNA degradation or repressing translation. MIR8084 is upregulated in breast cancer, where it acts as an oncogene (“oncomiR”) by promoting cell proliferation, migration, invasion, and suppressing apoptosis. Its oncogenic effects are linked to downregulation of the tumor suppressor *ING2*, as well as activation of signaling pathways such as ERK1/2 and AKT and suppression of the p53-BAX apoptosis axis. MIR8084 is detectable in serum and tumor tissue, suggesting utility as a non-invasive diagnostic or prognostic biomarker in breast cancer. Although it is a potential therapeutic target, there are no current drugs directly approved for MIR8084, and more research is required into risk and clinical applicability[1].
- Other names
- hsa-mir-8084miR-8084microRNA mir-8084
02
Biological functions
Regulation of gene expression (post-transcriptional)Promotion of cell proliferationInhibition of apoptosisEnhancement of cell migration and invasion (epithelial–mesenchymal transition/EMT)Tumorigenesis
03
Disease associations
Cancer, specifically breast cancer (oncomiR)Potentially involved in other conditions such as osteoporosis and epithelial ovarian tumor (as suggested by limited early studies)
04
Safety considerations
Therapeutic targeting of microRNAs may have broad off-target effects due to their regulation of multiple genes.Lack of clinical trials or safety data for direct targeting of miR-8084 in patients (as of current research)
05
Biomarkers
Diagnostic biomarker for breast cancer (detectable and elevated in serum and tissue of breast cancer patients)
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