MicroRNA 8485 (miR-8485)

MicroRNA 8485 (miR-8485, hsa-mir-8485, MIR8485) is a small, single-stranded, non-coding RNA molecule classified as a microRNA (miRNA) that plays a key post-transcriptional regulatory role in gene expression[1][2]. Like other miRNAs, it functions primarily by binding to complementary sequences in target messenger RNAs (mRNAs), typically leading to the repression, destabilization, or cleavage of those mRNAs and thereby modulating protein production[2]. MIR8485 has been implicated in autophagy regulation through binding to LAMTOR3, which downregulates mTOR and increases autophagy markers such as ATG13 and LC3-II[1]. It has been associated with variance in mRNA expression between adult and young animals, suggesting a role in age-related molecular processes[1]. In cancer, MIR8485 is found in exosomes from certain tumor cells (e.g., HCC827 cells), and targets genes within the p53 signaling pathway, thus being involved in cell cycle regulation and apoptosis[1]. Mutations or dysregulation of MIR8485 have been linked to neurodegenerative processes via overexpression of neurexin 1 (NRXN1), causing presynaptic Ca2+ overload and mitochondrial dysfunction[1]. There are currently no approved drugs that specifically target miR-8485, nor is it a typical therapeutic "target" like a protein receptor or enzyme; its primary scientific and clinical interest lies in its regulatory effects on gene expression and disease association[1][2].

Other names

hsa-mir-8485MIR8485