MicroRNA 876 (miR-876)

MicroRNA 876 (miR-876) is a non-coding RNA molecule classified as a microRNA that functions primarily in the post-transcriptional regulation of gene expression by binding to the 3′-untranslated region of messenger RNAs, resulting in their degradation or translational repression[7]. It is transcribed as part of a primary transcript, processed by Drosha and Dicer into its mature form, and involved in diverse biological processes. Functionally, miR-876 has been shown to act as a tumor suppressor in multiple cancer types by targeting oncogenes such as c-Met in osteosarcoma, BCL-XL in cholangiocarcinoma, and TGFBR1 in gastric cancer, leading to suppression of cell proliferation, migration, invasion, and promotion of apoptosis[1][2][3]. In infectious diseases, miR-876-5p also modulates the host response, with elevated levels reported in severe viral infections such as Enterovirus 71 and involvement in antiviral defense mechanisms[4][1]. miR-876 may thus serve as a potential therapeutic target and biomarker for prognosis and severity assessment in oncology and infectious disease contexts[3][4][2].

Other names

hsa-mir-876MIR876MIRN876mir-876miR-876-5pmiR876-5pmiR-876-3pMIR876 microRNA

Suppresses tumorigenesis and metastasis by targeting oncogenes such as c-Met, BCL-XL, TGFBR1, BMP-4, MAGE-A, BCORL1, and DNMT3A. Modulates antiviral defense by targeting viral components. Regulates EMT by suppression of specific receptor or transcription factors.