MicroRNA 885 (miR-885 or MIR885)

MicroRNA 885 (miR-885 or MIR885) is a non-coding RNA molecule classified as a microRNA, functioning in post-transcriptional regulation of gene expression by guiding translational inhibition or degradation of target mRNAs[5][10]. It is encoded on human chromosome 3p25.3 and processed from a precursor hairpin into mature forms, notably miR-885-5p and miR-885-3p[1][3]. miR-885-5p is well characterized as a tumor suppressor in several cancers, including liver cancer and neuroblastoma, where it induces cell cycle arrest (notably at the G1/S transition), activates the p53 pathway, inhibits glycolysis by targeting HK2, impairs cell migration, and modulates autophagy and cell apoptosis[1][2][3][4][9]. It also acts as a negative regulator of autophagy and has specific roles in stemness and migration of melanoma cells[1]. Expression of miR-885-5p is altered in various disease states and is explored as a circulating biomarker for cancer metastasis, liver disease, pre-eclampsia, and possibly neurodegenerative conditions[3][8]. Recent work shows miR-885-5p can sensitize cells to CDK4/6 inhibitors, pointing to therapeutic implications[2][7]. As a broadly-acting regulatory RNA, safety considerations must account for off-target or systemic gene expression changes.

Other names

MIR885hsa-mir-885mir-885-5pmiR-885-5pmir-885-3pmicroRNA 885microRNA-885MIRN885

Modulates sensitivity to CDK4/6 inhibitors by downregulating cell cycle progression genes (e.g., CDK6, ORC1); induces cell cycle arrest; reduces proliferation; direct translational repression and destabilization of target mRNAs