MicroRNA 887 (miR-887)

MicroRNA 887 (miR-887) is a short (20–24 nucleotide), non-coding RNA molecule encoded in the human genome, classified as a microRNA[6]. MicroRNAs are transcribed by RNA polymerase II and modulate gene expression post-transcriptionally by binding to complementary sequences in the 3' untranslated regions (UTRs) of target mRNAs, leading to translational repression or mRNA degradation[1][3][6]. MiR-887 is found at elevated levels in breast cancer cell lines and is implicated in drug resistance through regulation of the Notch1/Hes1 signaling pathway, specifically by targeting BTBD7[6]. Inhibiting miR-887 can enhance the therapeutic effect of drugs such as 5-fluorouracil (5-FU) in breast cancer cells[5]. Like other microRNAs, miR-887 is considered both a potential therapeutic target and a biomarker for cancer diagnosis, prognosis, and therapy monitoring. Its broad regulatory capacity and ability to affect multiple mRNA targets highlight both its therapeutic potential and the complexity of developing miRNA-based interventions[6][5].

Other names

hsa-mir-887MIRN887MIR887hsa-mir-887-3p

Modulation of drug response by regulating gene expression of drug resistance-associated genes (e.g., targeting BTBD7 and activating the Notch1/Hes1 pathway in breast cancer[6])