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Target intelligence / Profile preview
microRNA-888 (miR-888)
- Target
- miR-888
- Molecular classification
- MicroRNA, Non-coding RNA, Regulatory RNA
01
Overview
microRNA-888 (miR-888) is a member of the microRNA family, a class of small non-coding RNAs (typically ~22 nucleotides) that regulate gene expression post-transcriptionally. miR-888 is primate-specific, X-linked, and has been identified as highly upregulated in aggressive forms of prostate cancer, promoting cell proliferation and migration by suppressing tumor suppressor genes. Elevated miR-888 levels in prostatic secretions and urine are associated with high-grade prostate cancer, indicating its promise as a diagnostic and prognostic biomarker, as well as a potential therapeutic target[2].
- Other names
- hsa-mir-888MIR888MIRN888
02
Mechanism of action
miR-888 negatively regulates the expression of target mRNAs by binding to their 3′UTRs, leading to repression of their translation or mRNA degradation, particularly suppressing tumor suppressor genes such as RBL1 and SMAD4[2].
03
Biological functions
Post-transcriptional gene regulationRepression of translationCell proliferationCell migrationSuppression of tumor suppressors
04
Disease associations
CancerSpecifically, aggressive prostate cancer
05
Safety considerations
Potential off-target effects due to broad influence on multiple mRNA targetsOncogenic effects if upregulated
06
Biomarkers
miR-888 levels in expressed prostatic secretions in urine (EPS urine) as a biomarker for prostate cancer progression and disease grade[2].
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