MicroRNA 9-3 (MIR9-3)

MicroRNA 9-3 (MIR9-3) is a member of the microRNA gene family that produces mature miR-9 microRNA. miR-9-3 is highly expressed in hematopoietic cells and mature neuronal tissue, acting as a key regulator of differentiation, especially in myeloid lineages and neuronal development[1][3]. It mediates biological effects by binding the 3'-UTR of target mRNAs—such as Forkhead box O (FoxO1, FoxO3) transcription factors—resulting in translational inhibition or degradation of those mRNA targets[1]. Dysregulation of MIR9-3 is implicated in multiple cancers, including breast cancer, pituitary adenoma, and leukemias, often due to epigenetic repression via DNA hypermethylation of its promoter in malignant cells[1][2]. MIR9-3’s tissue-specific expression and regulatory role make it notable both as a disease biomarker and as a potential, though currently untargeted, therapeutic molecule.

Other names

hsa-mir-9-3miRNA9-3mir-9-3MIRN9-3

Operates by mRNA silencing/post-transcriptional repression (therapeutic mechanisms not defined)