microRNA-922 (miR-922)

microRNA-922 (miR-922) is a small, non-coding RNA in humans that regulates gene expression at the post-transcriptional level and acts as an oncogenic factor in several diseases. It promotes *malignant behavior* in liver cancer by targeting and downregulating ARID2, a known tumor suppressor, ultimately increasing tumor cell proliferation, invasion, and reducing apoptosis[1]. In the context of Alzheimer's disease, miR-922 downregulates UCHL1, resulting in increased phosphorylation of tau protein, which contributes to the pathogenesis of neurodegenerative disease[2]. As with other microRNAs, its primary biological function is to bind to the 3′UTR of specific target mRNAs, leading to mRNA degradation or translational silencing. **There are currently no known direct drugs targeting miR-922, though it is being evaluated as a mechanistic biomarker and a potential therapeutic target in cancer and neurodegenerative research.** --- **Note:** - microRNA-922 is not a receptor, enzyme, transporter, or conventional drug target but is a regulatory RNA—an emerging drug target class. - No evidence indicates an error or artifact in the target’s naming or validity as presented in the curated scientific literature.[1][2]

Other names

MIR922hsa-mir-922MIRN922

Binds to the 3′UTR of target mRNAs (e.g., ARID2, UCHL1), downregulating their translation or stability[1][2]