MicroRNA-92a-3p (miR-92a-3p)

MicroRNA-92a-3p is a small, non-coding RNA molecule that functions as a post-transcriptional regulator of gene expression by binding to complementary sequences in target messenger RNAs (mRNAs), resulting in their silencing or degradation. It is part of the miR-17-92 cluster and is widely recognized for its role in promoting cancer cell proliferation, migration, invasion, and resistance to apoptosis by targeting tumor suppressor genes such as PTEN, KLF4, Nrf1, and BIM. miR-92a-3p is upregulated in a variety of cancers and is implicated in the development of chemoresistance to cisplatin, as well as in the pathogenesis of cardiovascular, renal, and neurodegenerative diseases. Modulating the activity of microRNA-92a-3p (using mimics or inhibitors) is an area of interest for emerging therapeutics and as a potential biomarker for disease progression and treatment response.

Other names

miR-92a-3pmiR-92-3phsa-miR-92a-3p

Antagomirs or inhibitors bind and sequester miR-92a-3p, reducing its function and restoring target gene expression. Mimics increase miR-92a-3p activity, further suppressing target mRNA expression. It alters cisplatin sensitivity in cancer by targeting apoptosis regulators such as BIM and Krüppel-like factor 4 (KLF4). It also modulates key tumor suppressors (PTEN) and regulators (Nrf1, SGK3).