microRNA-92b-3p (miR-92b-3p)

MicroRNA-92b-3p (miR-92b-3p) is a small, non-coding RNA molecule that serves as a critical post-transcriptional regulator of gene expression by binding to the 3' untranslated regions (UTRs) of target messenger RNAs (mRNAs) (GeneCards). It is involved in a wide array of biological processes, including cell proliferation, apoptosis, migration, and differentiation (PubMed). In many human malignancies, such as esophageal squamous cell carcinoma (ESCC) and hepatocellular carcinoma (HCC), miR-92b-3p acts as an oncogene (oncomiR), promoting tumor progression and metastasis by silencing tumor suppressor genes like KLF4 and CDKN1C (PubMed, ResearchGate). Beyond cancer, it plays significant roles in other pathological conditions, including the promotion of liver fibrosis via the JAK/STAT pathway and protection against myocardial ischemia-reperfusion injury by targeting MAP3K2 (PubMed). Due to its stable presence in biofluids, miR-92b-3p is being explored as a non-invasive diagnostic and prognostic biomarker, particularly in synovial sarcoma and colorectal cancer (PubMed). Therapeutic strategies targeting miR-92b-3p involve the use of synthetic antagomirs to neutralize its overexpressed oncogenic forms or miRNA mimics to replenish its levels when it acts as a suppressor (MedChemExpress). However, the clinical translation of these therapies faces challenges such as off-target effects and the need for efficient, tissue-specific delivery systems (PubMed).

Other names

hsa-miR-92b-3pMIR92BmiR-92b

Post-transcriptional gene silencing through mRNA degradation or translational inhibition by binding to the 3' UTR of target mRNAs such as CDKN1C, KLF4, and PTEN.