microRNA-941 (miR-941 or MIR941)

MicroRNA-941 is a human-specific, small non-coding RNA that functions as a post-transcriptional regulator of gene expression through sequence-specific binding to target mRNAs, resulting in mRNA degradation or translational repression[1][2][5]. It is highly expressed in pluripotent and cancer-derived human cells, but its levels decline during cellular differentiation[1][2]. In the brain, miR-941 modulates neurotransmitter signaling by regulating genes involved in synaptic transmission and plasticity[2]. It notably targets genes in the hedgehog and insulin signaling pathways, influencing processes such as cell proliferation, stem cell maintenance, and longevity[1][2]. Overexpression or aberrant regulation of miR-941 is associated with various diseases, primarily cancers, cardiovascular inflammation, and some autoimmune and neurodegenerative diseases[1][2][3][4]. Experimentally, inhibition of miR-941 has shown anti-cancer effects in vitro and in animal models, positioning this miRNA as a potential therapeutic target and biomarker for multiple disease states[1][3][4].

Other names

MIR941-5hsa-miR-941-5hsa-mir-941-5microRNA 941-5miR-941

miR-941 inhibitors hybridize with and neutralize mature miR-941, reducing its regulatory effects on target mRNAs, leading to diminished cancer cell growth and migration. DNA methyltransferase inhibitors upregulate miR-941 by demethylation of regulatory regions. By targeting specific genes in signaling pathways (e.g., hedgehog and insulin signaling), miR-941 modulates key components and affects downstream processes.