MicroRNA 941-3 (miR-941-3)

MicroRNA 941-3 (miR-941-3) is a short, non-coding RNA molecule involved in the post-transcriptional regulation of gene expression by targeting mRNAs for degradation or translational repression[1][4]. It originated specifically in the human lineage and exhibits polymorphic copy number in the population[6][7]. miR-941-3 regulates key cellular processes—including cell cycle, proliferation, apoptosis, differentiation, and immune function—by modulating histone modification (H3 Ser10 phosphorylation) and influencing various signaling pathways, such as MAPK, insulin, and T-cell receptor signaling[2][3][5]. Upregulation of miR-941-3 has been linked to enhanced cancer cell proliferation, especially in aggressive cancers like triple-negative breast cancer, while its presence in circulating plasma serves as a promising biomarker for acute coronary syndromes and cardiovascular injury[5]. Additionally, miR-941-3 is implicated in human neurological evolution, with roles identified in human brain development and neurotransmitter signaling[6][7]. While no approved drugs target miR-941-3, experimental inhibitors and antisense oligonucleotides have shown preclinical potential in sensitizing cancer cells to chemotherapy[2]. Safety concerns remain significant due to the broad regulatory effects of microRNAs and the potential for off-target impacts.

Other names

hsa-miR-941-3MIR941-3MIRN941-3hsa-mir-941-3

Inhibition leads to reduced cellular proliferation and migration (notably in cancer cells)[2][3]. Alters gene expression by downregulating target mRNAs post-transcriptionally[1][4]. Regulates cell-cycle by affecting histone H3 Ser10 phosphorylation[2][3]. Modulates signaling pathways involved in cancer, immunity, cardiovascular, and developmental systems[5][7].