MicroRNA let-7a-1 (MIRLET7A1)

MicroRNA let-7a-1 (encoded by MIRLET7A1, located on human chromosome 9q22.3) is a member of the let-7 microRNA family, which plays vital roles in controlling cell fate by post-transcriptional repression of target mRNAs. It acts as a tumor suppressor chiefly by regulating genes involved in cell cycle progression and differentiation, such as MYC, RAS, IGF1R, HMGA2, and CDC25A. Let-7a-1 also maintains genome stability by inhibiting retrotransposon activity, notably LINE-1 elements[1][3]. Dysregulation or deletion of MIRLET7A1 is implicated in various human cancers and may confer risk or protection in other disease contexts, including hematologic toxicity. Therapeutic manipulation of let-7a-1 is a subject of ongoing research but faces challenges due to the pleiotropic roles of microRNAs and the complexity of downstream effects[1][2][3][4][5].

Other names

hsa-let-7a-1LET7A1let-7a-1MIRNLET7A1

Drugs or molecular tools that increase let-7a-1 activity may suppress proliferation and induce apoptosis by inhibiting target oncogenesis-related genes (e.g., RAS, MYC, IGF1R, HMGA2); let-7a-1 downregulates mRNA translation by binding to complementary sequences via the RISC complex[1][4][5].