microRNA let-7a-2 (MIRLET7A2)

microRNA let-7a-2 (MIRLET7A2) is a member of the let-7 family of microRNAs, which are highly conserved non-coding RNAs functioning in post-transcriptional regulation of gene expression[3][4][5]. MIRLET7A2 is transcribed as a precursor miRNA, processed to the mature let-7a strand, and acts mainly by binding to complementary sequences on target mRNAs, leading to mRNA degradation or translational repression[2][3][5]. The let-7 family—including let-7a produced from MIRLET7A2—regulates key genes in cell division, differentiation, apoptosis, and development; notably, it acts as a tumor suppressor by repressing oncogenes such as MYC, RAS, and HMGA2[3][4][6]. Dysregulation of let-7a is implicated in multiple diseases—especially various cancers, where reduced let-7a correlates with poor prognosis[4][6]. Recent research also suggests that pre-miRNA hsa-let-7a-2 can bind directly to the AGTR2 receptor and antagonize its signaling, giving MIRLET7A2 a unique regulatory role beyond classical microRNA function[1]. No direct small-molecule drugs currently target this miRNA in routine clinical use, but miRNA mimics or inhibitors are being explored experimentally for therapeutic applications[6]. Downregulation of let-7a family members—including MIRLET7A2—serves as a clinical biomarker in some cancers, and therapeutic manipulation may affect broad biological pathways, posing potential safety risks due to widespread gene target interactions[4][6].

Other names

hsa-let-7a-2LET7A2MIRNLET7A2let-7a-2MIRLET7A2

Gene silencing via RNA-induced silencing complex (RISC), Binding and suppression of target mRNA translation, Negative regulation of AGTR2 signaling pathway