microRNA let-7c (MIRLET7C)

microRNA let-7c is a non-coding RNA and member of the highly conserved let-7 family of microRNAs, originally discovered for its role in developmental timing. In humans, let-7c acts as a post-transcriptional regulator by binding to the 3’ untranslated regions of target mRNAs, repressing genes involved in cell proliferation and differentiation such as MYC, RAS, and CDC25A. Let-7c is widely recognized as a tumor suppressor, commonly downregulated in various cancers including prostate cancer and hepatocellular carcinoma, where its restoration inhibits tumor cell proliferation, induces apoptosis, and suppresses tumor growth in vivo. Let-7c also plays key roles in neural differentiation and is implicated in disease processes beyond cancer, including as a biomarker and potential therapeutic target[1][2][4][5][6][12][13].

Other names

hsa-let-7cLET7CMIRNLET7Clet-7cMIRLET7C-1MIRLET7C-2

Silencing of target oncogenes (e.g., MYC, RAS, AR, CDC25A) via mRNA degradation or translational repression[1][2][4][12]. Negative feedback on Lin28/let-7c axis[2].