microRNA let-7e (MIRLET7E)

MicroRNA let-7e (MIRLET7E, hsa-let-7e) is a member of the let-7 family, one of the most evolutionarily conserved microRNA families, and plays a prominent role in regulating developmental timing, stem cell differentiation, and tumor suppression[1][6]. Like other let-7 family members, let-7e functions by binding to the 3' untranslated regions (UTRs) of target mRNAs, promoting their degradation or inhibiting their translation, thus suppressing genes associated with cell cycle progression and proliferation (notable targets include HMGA2, MYC, and RAS)[1][8]. Let-7e is commonly underexpressed in many cancers, and its low expression is associated with poor prognosis, especially in gastrointestinal stromal tumors and leukemia, making it a potential prognostic biomarker and therapeutic target[2][5][10]. miRNA mimics and targeted RNA delivery systems are being explored as therapeutic options, but challenges remain in delivery specificity and safety, particularly with respect to effects on normal tissue and immune response[5]. Let-7e also participates in immune regulation and is implicated in response to viral infections, further broadening its biological and pathological significance[3].

Other names

hsa-let-7eLET7EMIRNLET7Elet-7eMIRLET7E

Post-transcriptional gene silencing via RNA-induced silencing complex (RISC) Direct binding to target mRNAs (such as HMGA2, MYC, RAS, cyclin D, CDC25A, LIN28) Suppression of oncogene translation and stemness pathways[1][8]