MicroRNA let-7f (let-7f) (let-7f)

MicroRNA let-7f is a member of the highly conserved let-7 family of microRNAs, which are critical regulators of gene expression across various biological processes (Roush & Slack, 2008). It functions primarily by binding to the 3' untranslated regions (UTRs) of target messenger RNAs (mRNAs), leading to their degradation or the inhibition of their translation (Boyerinas et al., 2010). In a physiological context, let-7f is crucial for cell differentiation, developmental timing, and maintaining cellular homeostasis.\n\nIn many human malignancies, such as lung and breast cancer, let-7f acts as a potent tumor suppressor, and its downregulation is often associated with poor prognosis and advanced disease stages (Yanaihara et al., 2006). It exerts its anti-tumor effects by silencing key oncogenes, including RAS and MYC. Consequently, let-7f is being explored as a therapeutic target, with research focusing on the development of miRNA mimics to restore its function in cancer cells. However, the clinical application of let-7f-based therapies faces hurdles such as efficient delivery to target tissues and the potential for off-target silencing of unintended genes (Trang et al., 2008). Beyond oncology, let-7f has been implicated in regulating inflammatory responses and cardiovascular health, suggesting a broader therapeutic potential.

Other names

hsa-let-7fMIRLET7Flet-7f-5plet-7f-3pMicroRNA let-7f-1MicroRNA let-7f-2

RNA interference-mediated gene silencing via mRNA degradation or translational inhibition.