MicroRNA let-7g (MIRLET7G)

MicroRNA let-7g (MIRLET7G) is a highly conserved, small non-coding RNA that functions mainly as a tumor suppressor by regulating gene expression at the post-transcriptional level. It belongs to the let-7 family, one of the first-discovered and most studied microRNA families, playing a crucial role in controlling cell differentiation, proliferation, and developmental timing. MIRLET7G acts primarily by binding to complementary sequences in target mRNAs, leading to translational repression or mRNA degradation, with key targets including oncogenes such as MYC, RAS, and HMGA2. Dysregulation or reduced expression of let-7g contributes to tumorigenesis and is associated with poor clinical outcomes in various cancers. Therapeutic strategies are under exploration using let-7g mimics or inducers to restore its tumor suppressor function, although challenges remain regarding delivery, specificity, and safety[1][4][5][7].

Other names

LET7Glet-7gMIRNLET7Ghsa-let-7gMIRLET7G[1][7]

miRNA mimics: Increase let-7g activity to suppress oncogene expression. Antagomirs/inhibitors: Block let-7g, increasing expression of its targets. Indirect: Drugs affecting let-7g regulators (e.g., LIN28 inhibition increases let-7g levels).