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Target intelligence / Profile preview
microRNA miR-22 (MIR22)
- Target
- MIR22
- Molecular classification
- Non-coding RNA, microRNA
01
Overview
microRNA miR-22 (MIR22) is a small non-coding RNA molecule that regulates gene expression post-transcriptionally. It plays a critical role in various cellular processes, including cancer biology and cardiac function, and can act as both a tumor suppressor and an oncogene depending on the context. Its expression is altered in various diseases, making it a potential biomarker and therapeutic target.
- Other names
- mir-22
02
Mechanism of action
Binds to 3' UTR of target mRNAs, leading to mRNA degradation or translational repression.
03
Biological functions
Post-transcriptional regulationRegulation of gene expressionCell proliferationApoptosisEpithelial-mesenchymal transition (EMT)Cardiac remodelingAutophagy
04
Disease associations
CancerRenal Cell CarcinomaHepatocellular CarcinomaPanic DisorderCardiovascular Disease
05
Safety considerations
Context-dependent function as tumor suppressor or oncogenePotential off-target effects
06
Biomarkers
miR-22 expression levels
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