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Target intelligence / Profile preview
MicroRNA MIR133 Family (miR-133)
- Target
- miR-133
- Molecular classification
- Non-coding RNA, MicroRNA
01
Overview
The microRNA MIR133 family (miR-133) is a group of highly conserved non-coding RNAs that regulate gene expression at the post-transcriptional level. Predominantly expressed in muscle tissues, miR-133 plays crucial roles in muscle development and function, cardiovascular homeostasis, and acts as a tumor suppressor in various cancers. It functions by binding to target mRNAs via the RISC complex, leading to translational repression or mRNA degradation.
- Other names
- mir-133a-1mir-133a-2mir-133bMIR133 family
02
Mechanism of action
Post-transcriptional repression via RISC complex leading to translational repression/mRNA degradation.
03
Biological functions
Gene silencing by RNAMicroRNA mediated inhibitionRegulation of myogenesisSuppression of non-muscle gene expressionCardiac homeostasisRegulation of cell proliferationRegulation of cell differentiationRegulation of cell survivalRegulation of hypertrophic growthRegulation of electrical conduction of cardiac cells
04
Disease associations
Cardiovascular diseasesCancersCardiac HypertrophyHeart FailureArrhythmiasMuscular Dystrophies
05
Safety considerations
Dysregulation can contribute to disease progression.Aberrant expression linked with several diseases.
06
Biomarkers
Diagnostic and prognostic marker in cardiovascular diseasesPotential therapeutic target in vascular diseasesTumor suppressor in various cancers
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