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MicroRNA-Protein Interaction (miRNA-Protein Interaction)
- Target
- miRNA-Protein Interaction
- Molecular classification
- Non-coding RNA, RNA-binding proteins (RBPs), Argonaute proteins
01
Overview
MicroRNA-protein interactions encompass the molecular relationships between microRNAs (miRNAs) and proteins, particularly those involved in gene regulation. miRNAs primarily function as post-transcriptional regulators by binding to complementary sequences on target messenger RNAs (mRNAs), leading to mRNA degradation or translational repression. Argonaute proteins are central to this process, forming the core of the microRNA-induced silencing complex (miRISC) and mediating gene silencing. Numerous other RNA-binding proteins (RBPs) interact with various stages of miRNA precursors, influencing their processing, stability, and function. These interactions influence a wide array of biological processes including development, differentiation, apoptosis, metabolism, immune responses, and cancer progression.
- Other names
- miRNA-RBP interactionmicroRNA-induced silencing complex (miRISC)miRNA regulationmicroRNA-mRNA interactionRNA-induced silencing complex (RISC)
02
Biological functions
Post-transcriptional gene regulationmRNA degradationTranslational repressionRegulation of developmentRegulation of differentiationRegulation of apoptosisRegulation of metabolismRegulation of immune responsesRegulation of cell proliferationRegulation of cell death
03
Disease associations
CancerInflammationNeurodegenerative diseaseCardiovascular diseaseInfection
04
Safety considerations
Off-target effects of miRNA therapeuticsDelivery challenges for miRNA therapeuticsUnintended consequences of altering miRNA networks
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