Microsomal glutathione S-transferase 3 (MGST3)

Microsomal glutathione S-transferase 3 (MGST3) is a membrane-associated enzyme of the glutathione S-transferase superfamily, classified within the MAPEG family. It plays a central role in cellular detoxification by catalyzing the conjugation of reduced glutathione to reactive lipid peroxidation products and xenobiotic electrophiles, reducing oxidative cellular damage. MGST3 demonstrates both glutathione transferase and peroxidase activities, notably in the biosynthesis of leukotriene C4 and the reduction of lipid hydroperoxides. MGST3 is implicated in inflammation and neuroanatomical modulation, with genetic variability affecting susceptibility to neurodegenerative and inflammatory diseases. Its enzymatic activity is essential for regulating oxidative stress and maintaining neuronal health[1][3][4].

Other names

GST-IIIglutathione S-transferase 3, mitochondrialmicrosomal glutathione S-transferase IIILTC4 synthase MGST3glutathione peroxidase MGST3microsomal GST-3micrososomal GST-III

Drugs that inhibit or modulate MGST3 would alter cellular detoxification of electrophilic compounds and lipid peroxides, and may influence eicosanoid/inflammatory mediator biosynthesis. Agents targeting glutathione S-transferase activity could impact oxidative stress response.