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Prostaglandin E Synthase (PGES)
- Target
- PGES
- Molecular classification
- Enzyme, MAPEG (membrane-associated proteins involved in eicosanoid and glutathione metabolism), Isomerase
01
Overview
Prostaglandin E synthase (PGES) is an enzyme that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2). PGE2 is a key eicosanoid involved in inflammation, pain, fever, and various physiological and pathological processes. There are three main isozymes: mPGES-1 (inducible, inflammatory), mPGES-2 (constitutive), and cPGES (constitutive).
- Other names
- PGES-1PGES-2cPGESmPGES-1mPGES-2Microsomal Prostaglandin E Synthase-1Microsomal Prostaglandin E Synthase-2Cytosolic Prostaglandin E Synthase
02
Mechanism of action
Inhibition of PGE2 synthesis by blocking the conversion of PGH2 to PGE2
03
Biological functions
Prostaglandin biosynthesisInflammationPain modulationFever inductionCell proliferationTumor growthImmune responseGastrointestinal protectionRenal function regulation
04
Disease associations
InflammationPainCancerInflammatory diseasesOther
05
Safety considerations
Potential for off-target effects on other prostanoid pathwaysRisk of disrupting homeostatic PGE2 functions
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