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Microtubule associated protein 1 light chain 3 beta pseudogene 1 (MAP1LC3BP1)
- Target
- MAP1LC3BP1
- Molecular classification
- Other (pseudogene), Non-coding RNA
01
Overview
MAP1LC3BP1 is a human pseudogene related to the functional MAP1LC3B gene, which encodes the widely studied LC3B protein involved in autophagy. As a pseudogene, MAP1LC3BP1 does not encode a functional protein product, but its RNA sequence may play a role in the post-transcriptional regulation of MAP1LC3B and other genes through a competing endogenous RNA (ceRNA) mechanism, acting as a decoy for miRNAs that target its functional parent gene. While pseudogenes in general are increasingly recognized as relevant in gene regulation and disease (especially in cancer), there is currently no direct evidence that MAP1LC3BP1 acts as a therapeutic target, biomarker, or has a well-delineated disease role[3][5][7].
- Other names
- microtubule-associated proteins 1A/1B light chain 3B-like, pseudogene 1MAP1LC3B pseudogene 1MAP1LC3BP1
02
Biological functions
Competes for microRNA binding as a competing endogenous RNA (ceRNA) with its parental gene transcripts (likely MAP1LC3B)Potential regulation of MAP1LC3B gene expression via miRNA decoy activity (extrapolated from the established functions of other pseudogenes)May interact with RNA-binding proteins
03
Disease associations
Other (no direct evidence MAP1LC3BP1 itself is involved in disease, but pseudogene-mediated ceRNA regulation is implicated broadly in cancer and other pathologies)No known direct role in cancer, inflammation, or neurodegeneration specific to MAP1LC3BP1
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