Microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C)

Microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C) is a ubiquitin-like autophagy-related protein and member of the ATG8 family[5][6]. It is involved in the selective and bulk autophagy processes, especially through recruitment and interaction with adapter proteins presenting LC3-interacting regions (LIRs)[2][4]. MAP1LC3C distinguishes itself by a unique N-terminal extension containing a polyproline II motif and a phosphorylation-regulated interface, contributing to specific microtubule and protein interactions; its principal roles encompass autophagosome formation, elongation, selective cargo recognition, and degradation of intracellular pathogens and protein aggregates[4][6]. Pathological relevance includes neurodegenerative diseases, hereditary spastic paraplegia, antibacterial responses, and selective autophagy in cancer and cellular differentiation[5][6][1]. Robust antibody specificity and aggregation tendencies present challenges for both research and potential therapeutic exploitation[6].

Other names

Microtubule-associated protein 1 light chain 3 gammaMAP1LC3CMicrotubule-associated proteins 1A/1B light chain 3CMAP1A/MAP1B LC3 CATG8JAutophagy-related protein LC3 CAutophagy-related ubiquitin-like modifier LC3 CMAP1 light chain 3-like protein 3LC3CMAP1A/MAP1B light chain 3 Cmicrotubule-associated proteins 1A/1B light chain 3C

Drugs modulating autophagy (e.g., autophagy inducers or inhibitors) may influence MAP1LC3C-dependent pathways, typically by affecting autophagosome formation or lysosomal fusion, but MAP1LC3C is not a direct drug target according to current data[5][6].