Microtubule-associated protein 1 light chain 3 pseudogene (MAP1LC3P)

Microtubule-associated protein 1 light chain 3 pseudogene (MAP1LC3P) is a human pseudogene, not a functional protein-coding gene[1][7]. Like other pseudogenes, it may superficially resemble protein-coding family members such as MAP1LC3A/B/C, but MAP1LC3P itself does not produce a functional protein and is not considered a therapeutic target. Pseudogenes have increasingly been studied for their possible regulatory roles on their parent genes, such as acting as competing endogenous RNAs or miRNA decoys, but no direct functional or therapeutic relevance is established for MAP1LC3P[4][10]. The entries MAP1LC3A, MAP1LC3B, and MAP1LC3C encode proteins of the ATG8/LC3 family involved in autophagy, but these should not be confused with the pseudogene[2][5][6]. Thus, MAP1LC3P is not a druggable or classical pharmacological target. Key Points: - This entry refers to a pseudogene, not a functional protein. - It does not encode a receptor, enzyme, transporter, or other classical therapeutic target. - There is no evidence for direct drug interaction, biological function, or disease linkage relevant to therapies. - Functional MAP1LC3 proteins (without P, e.g., MAP1LC3B) are sometimes drug targets in autophagy research but are distinct from the pseudogene[6][9]. - If you are interested in the autophagy-related gene, you likely want "Microtubule-associated protein 1 light chain 3 beta (MAP1LC3B)" or similar, not the pseudogene.

Other names

HsT312