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Target intelligence / Profile preview
Microtubule-associated protein 2 (MAP2)
- Target
- MAP2
- Molecular classification
- Microtubule-associated protein
01
Overview
Microtubule-associated protein 2 (MAP2) is a neuron-specific cytoskeletal protein that plays a critical role in the structure, function, and plasticity of neurons. It exists as several isoforms (MAP2A, MAP2B, MAP2C, MAP2D) and is predominantly localized to the cell bodies and dendrites of neurons. MAP2 stabilizes microtubules, promotes their assembly, and crosslinks them with other cytoskeletal elements. It is dynamically regulated by various signals and its dysregulation has been observed in neuropsychiatric and neurodegenerative disorders. Antibodies against MAP2 are widely used as markers for identifying neuronal cells.
- Other names
- MAP-2
02
Biological functions
Microtubule stabilizationMicrotubule assemblyNeuritogenesisSynaptic plasticityIntracellular transportRegulation of neurite outgrowth/extensionModulation of protein folding/transport
03
Disease associations
Neuropsychiatric disordersNeurodegenerative disorders
04
Safety considerations
Dysregulation can impair neurite outgrowthDysregulation can cause synaptic dysfunctions
05
Biomarkers
Marker for neuronal cells
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