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Microtubule-Associated Protein 4 (MAP4)
- Target
- MAP4
- Molecular classification
- Microtubule-Associated Protein
01
Overview
Microtubule-associated protein 4 (MAP4) is a major non-neuronal microtubule-associated protein ubiquitously expressed and playing a central role in regulating microtubule stability, assembly, and dynamics. It binds directly to tubulin subunits and is involved in various cellular processes, with altered expression or phosphorylation implicated in diseases like cancer and cardiac conditions.
- Other names
- Microtubule associated protein 4
02
Mechanism of action
MAP4 stabilizes microtubules by binding directly to tubulin dimers and counteracting destabilization events. Phosphorylation regulates its binding affinity to microtubules.
03
Biological functions
Microtubule stabilizationMicrotubule assemblyRegulation of intracellular transportCell divisionCell migrationVesicular transportPrimary cilia formationImmune synapse formationWound healingHeart muscle function
04
Disease associations
CancerCardiac disease
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