Microtubule-associated protein 7 domain-containing protein 1 (MAP7D1)

Microtubule-associated protein 7 domain-containing protein 1 (MAP7D1) is a structural protein primarily involved in the stabilization and organization of microtubule cytoskeletons within cells[1][3][5]. It localizes to the centrosome and spindle, facilitating microtubule stability and influencing cellular processes such as motility and neurite outgrowth[1][3][5]. MAP7D1 is also important for the maintenance of acetylated microtubules, which are associated with stable cellular structures[1]. It is predominantly expressed in the brain, muscle, and reproductive tissues[2][6]. While not a direct therapeutic target or receptor, genetic disruption of MAP7D1 increases susceptibility to doxorubicin-induced cardiomyopathy and heart failure, making it a potential biomarker for predicting adverse effects in cancer therapy involving anthracyclines[2].

Other names

MAP7D1KIAA1187PARCC1RPRC1PP2464FLJ10350FLJ39022Arginine/proline-rich coiled-coil domain-containing protein 1Proline/arginine-rich coiled-coil domain-containing protein 1MAP7 domain-containing protein 1arginine/proline rich coiled-coil 1proline arginine rich coiled coil 1